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齐多夫定相关性肌病 被引量：3

Zidovudine-induced myopathy
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摘要 齐多夫定(AZT)为核苷类似物,是治疗艾滋病病毒感染的一线药物。自1987年开始陆续有AZT相关肌病的报道,其发生率为2%～18%。临床表现为肌痛、肌无力和肌酶升高。AZT引起肌病的机制可能和骨骼肌线粒体受损有关。其防治方法包括:(1)治疗时开始用小剂量,之后逐渐增加至规定剂量。(2)治疗过程中监测肌酶水平。(3)一旦确定肌病和齐多夫定有关应立即停药,并可应用糖皮质激素、辅酶Q、肉碱等药物治疗。 Zidovudine is a nucleoside analogue, which is the first - line drug for the treatment of AIDs. Since 1987, zidovudine associated myopathy has been sometimes reported. The incidence is 2% -18%. The clinical presentation is myalgia, muscle weakness and creatine kinase elevations. The mechanism of zidovudine-induced myopathy might be linked to the damage of skeletal muscle mitochondria. The prevention and treatment include ： （ 1 ） on the treatment, the low-dose of zidovudine should be initially given and then gradually increasing to regular dosage. （2） the levels of creatine kinase should be monitored during the treatment. （3） if zidovudine- induced myopathy is confirmed, the drug should be stopped immedialely, and corticosteroids, coenzyme Q10, and carnitine may be given.
作者 田慧军 张家堂
机构地区 中国人民解放军总医院神经内科
出处 《药物不良反应杂志》 2009年第5期335-339,共5页 Adverse Drug Reactions Journal
关键词 齐多夫定 不良反应 肌病 线粒体DNA zidovudine adverse reactions myopathy mitochondrial DNA
分类号 R595.3 [医药卫生—内科学]
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参考文献34

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共引文献2

同被引文献61

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药物不良反应杂志
2009年 第5期

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