呋喃唑酮引起幼儿急性肝损害

Acute liver damage caused by furazolidone in a young child

患儿女,1岁,因感染性腹泻伴轻度脱水入院。给予头孢曲松、利巴韦林治疗。入院第4天由于感染未控制,加用呋喃唑酮30mg,3次/d。3d后患儿出现皮肤及巩膜黄染;肝功能检查:ALT196U/L,AST67U/L,TBil71.2μmol/L,DBil61.4μmol/L,IBil9.8μmol/L。停用呋喃唑酮,继续用头孢曲松及利巴韦林,并行对症治疗。1周后黄疸消退,肝功能正常。

A one-year-old female child was hospitalized with infectious diarrhea complicated by mild dehydration. Ceftriaxone and ribavarin were given. On day 4 after admission,furazolidone 30 mg thrice daily was added to the regimen due to poor control of infections. Three days later,the patient presented with yellowish skin and sclera. Liver function examination revealed following levels ：ALT 196 U/L,AST 67 U/L,TBil 71.2 μmol/L,DBil 61.4 μmol/L,IBil 9.8 μmol/L. Furazolidone was stopped,ceftriaxone and ribavarin were continued, and symptomatic therapy was given. One week later, her jaundice disappeared and liver function normalized.