摘要
目的探讨心脏肌钙蛋白I(cTnI)测定对心血管疾病心肌损伤的诊断价值。方法用固相层析免疫法测定急性心肌梗死(AMI),心绞痛(AP)、病毒性心肌炎(VM)、原发性高血压(EH)和射频消融(RFCA)术后患者血清cTnI。结果 AMI、 VM和 RFCA术后患者血清 cTnI阳性率显著高于正常人(P<0.005)。 AMI组cTnI强阳性者较其他组显著增多(P均<0. 001), I多数2周内转阴;而 VM组和 RFCA组弱阳居多( P=0. 2), VM患者多于1个月左右转阴; RFCA术后 72h内即可转阴。 cTnI测定敏感性高于心肌酶学(P<0.005)。结论 cTnI是一特异性和敏感性具佳的心肌损伤血清标志物,对不同病理改变及不同病理进程的心肌损伤之诊断具有重要应用价值。
To discuss the diagnostic value of cardiac troponin Ⅰ (cTnI) in detection of myocardial injury in cardiovascular diseases. Methods Solid-phase immunochromatographicassay was used to detect serum cTnI in patients with acute myocardial infarction (AMI), angina pectoris (AP), essential hypertension (EH) and viral myocarditis (VM), and the patients after radiofrequency catheter ablation (RFCA). Results The positive rate of cTnI in sera of patients with AMI, VM and the patients after RFCA were significantly greater than that in the normal (P<0.005). The cases of cTnI strong-positive in AMI group were higher than those in others while the cases of cTnI weak-positive increased highly both in VM groupsand in the group after RFCA (P= 0. 2). The time of cTnI turning negative was 2 weeks, 1 month and 3 days in major patients with AMI, VM and the patients after RFCA respectively The sensitivity of cTnI was superior to serum enzymes (P<0.005). Conclusion cTnI wasagood serum marker to evaluate myocardial injury, and it might be useful to diagnose myocardial injury in different pathological changes and processes.
出处
《中国实验诊断学》
1998年第5期255-257,共3页
Chinese Journal of Laboratory Diagnosis
基金
福建省重点科技项目基金