水苏碱在家兔体内的药物动力学研究

Pharmacokinetics of Stachydrine in Rabbits

目的:研究水苏碱在家兔体内的药物动力学。方法:采用HPLC法测定从家兔耳静脉注射盐酸水苏碱溶液后不同时间的血浓度。用3P97药动学程序对血药浓度-时间数据进行拟合。结果:主要药动学参数为AUC=1712.50min·μg·ml^(-1),Vc=11.80L·kg^(-1),t_(1/2α)=32.46(min),t_(1/2β)=189.61min,K_(21)=3.97×10~3min^(-1),K10=1.97×10~2min^(-1),K_(12)=1.36×10min^(-1),CLs=0.23L·kg^1·min^(-1)。结论:水苏碱在家兔体内呈二室模型。

Objective： To study the pharmaeokineties of stachydrine in rabbits. Method： The HPLC method for determination of staehydrine in rabbits plasma was established after intravascular injection. The data were processed with the software 3P97. Result： The main pharmaeokinetie parameters were as follows ： A UC = 1712.50 （ min·μg^-1·ml^-1 ） , Vc = 11.80 （ L·kg^-1 ） , T1/2α = 32.46 （min ） , t1/2β=189.61（min）,K21 =3.97 ×10^-3（min^-1） ,K10 =1.97 ×10^-2（min^-1）,K12 =1.36×10^-3（min^-1）,CLs=0.23（L.kg^-1. min^-1 ）. Conclusion： The pharmacokinetic of staehydrine in rabbits fited to 2-compartment mode.