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地特胰岛素的药理作用与临床应用进展 被引量：9

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摘要 糖尿病现已成为威胁全球人类健康的一种重要疾病，2007年我国糖尿病患者人数约有4000万，仅次于印度，居全球第二位，糖尿病及其并发症的发生，不仅给患者带来了极大的痛苦，还给个人、家庭和社会带来了沉重的经济负担。
作者 赵丹 修锐 邵建芳
机构地区 沈阳军区大连第一疗养院药剂科 大连市药品不良反应监测中心
出处 《中国药师》 CAS 2009年第12期1728-1730,共3页 China Pharmacist
关键词 地特胰岛素 胰岛素类似物 糖尿病
分类号 R977.15 [医药卫生—药品]
  • 相关文献

参考文献13

  • 1陆志诚.地特胰岛索:作用时间长达一天[N].医药经济报,2006-01-25,C7版.
  • 2孙嘉,蔡德鸿.基础胰岛素新剂型——地特胰岛素[J].药品评价,2008,5(12):575-578. 被引量：6
  • 3潘长玉,陆祖谦.新一代长效胰岛素:地特胰岛素[N].中国医学论坛报,2008-08-21.C8版.
  • 4Ellmer M, Hamilton WM, Kim SP,at al. Mechanism of action in dogs of slow- acting insulin analog 0346 [J]. Clin Erulocrinol Metab, 2003, 88 ( 5 ) : 2256- 2262.
  • 5Havelund S,Plum A,Ribel U, et al. The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin [ J ]. Pharm Res, 21304,8 : 1498-1504.
  • 6苏杰英,李宏亮,杨文英.地特胰岛素的作用机制与安全性研究进展[J].药品评价,2008,5(10):430-433. 被引量：6
  • 7Plank J, Bodenlenz M, Sinner E. A double-blind, Vandomized dose-response study investigating the pharroacodynarnic and pharmacoknetic properties of long- acting insutlin analog detemir[J]. Diabetes Care, 2005, 28 : 1107-1112.
  • 8Heise T, Nosek L, Ronn RR. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine people with typel eliabetes[ J ]. Diabetes, 2004,53 : 1614-1620.
  • 9Hermansen K, Davies M, Dereznski T, et al. A 26week, randomized, par-alled treat-to-target-lrial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-na? ve people with type2 diabetes[J]. Diabetes Care, 2006, 29(6): 1269-1274.
  • 10Klein O, Lynge J, Endahl L. Albumin-bound basal insulin anaolgues( insulin detemir and NN344) :Comparable time-action profiles but less variability than insulin glargine in type 2 diabetes[J]. Diabets, Obasiey and Metabolism, 2007, 9:290 -299.

二级参考文献4

  • 1S. V. M. Hordern,J. E. Wright,A. M. Umpleby,F. Shojaee-Moradie,J. Amiss,D. L. Russell-Jones. Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp[J] 2005,Diabetologia(3):420～426
  • 2Svend Havelund,Anne Plum,Ulla Ribel,Ib Jonassen,Aage V?lund,Jan Markussen,Peter Kurtzhals. The Mechanism of Protraction of Insulin Detemir, a Long-Acting, Acylated Analog of Human Insulin[J] 2004,Pharmaceutical Research(8):1498～1504
  • 3A. M. Hennige,T. Sartorius,O. Tschritter,H. Preissl,A. Fritsche,P. Ruth,H.-U. H?ring. Tissue selectivity of insulin detemir action in vivo[J] 2006,Diabetologia(6):1274～1282
  • 4S. V. M. Hordern,J. E. Wright,A. M. Umpleby,F. Shojaee-Moradie,J. Amiss,D. L. Russell-Jones. Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycaemic clamp[J] 2005,Diabetologia(3):420～426

共引文献10

同被引文献44

  • 1肖新华.1型糖尿病的治疗新进展[J].国外医学（内分泌学分册）,2004,24(4):281-282. 被引量：7
  • 2祝群.新诊断2型糖尿病患者的短期胰岛素强化治疗意义[J].中国实用内科杂志,2005,25(6):560-560. 被引量：48
  • 3孙颖,潘琦.甘精胰岛素的临床评价[J].药物不良反应杂志,2007,9(3):220-224. 被引量：10
  • 4高剑坤,蔡绍皙,范开,龙波.2种新型基因工程长效人胰岛素类似物[J].中国新药与临床杂志,2007,26(7):548-552. 被引量：18
  • 5陈灏珠,林果为.实用内科学[M].第13版.北京:人民卫生出版社,2009:2005-2011.
  • 6陈灏珠,林果为.实用内科学[M].13版.北京:人民卫生出版社,2009:919.
  • 7World Medical Association. Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Patients. 52nd WMA General Assembly, Edinburgh, Scotland, October 2000. Last amended with Note of Clarification on Para graph 29 by the WMA General Assembly, Washington 2002, and Note of Clarification on Paragraph 30 by the WMA General assembly, Tokyo 2004.
  • 8Havelund S, Plum A, Ribel U, et al. The mechanism of protraction of insulin detemir, a long-acting, acylated analog of human insulin. Pharm Res, 2004, 8: 1498-1504.
  • 9Davies MJ, Derezinski T, Pedersen CB, et al. Reduced weight gain with insulin detemir compared to NPH insulin is not ex- plained by a reduction in hypoglycemia. Diabetes Technol Ther, 2008, 101 273-277.
  • 10Bush MA. Intensive diabetes therapy and body weight: focus on insulin detemir. Endocrinol Metab Clin North Am, 2007, 36 : S33-S44.

引证文献9

二级引证文献59

中国药师
2009年 第12期

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