摘要
目的:考察多索茶碱注射液、甲磺酸酚妥拉明注射液及盐酸多巴胺注射液的配伍稳定性。方法:观察及测定3种注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后于室温放置24h内的外观、pH及不溶性微粒,并采用高效液相色谱法测定配伍液中3种主药的含量。结果:多巴胺及酚妥拉明不影响多索茶碱的稳定性,配伍液pH对甲磺酸酚妥拉明、盐酸多巴胺的稳定性影响较大。结论:多索茶碱注射液、甲磺酸酚妥拉明注射液及盐酸多巴胺注射液适以5%葡萄糖注射液作溶媒配伍于24h内使用,不宜与0.9%氯化钠注射液配伍使用。
Objective: To study the compatibility and stability of doxofylline injection, phentolamine mesilate injection and dopamine hydrochloride injection. Method : The changes in appearance, particles and pH value of the mixture of the two injections in 0.9% sodium chloride injection and 5% glucose injection within 24 h at ambient temperature were observed. The concentrations of the mixture of the three injections in 0.9% sodium chloride injection and 5% glucose injection were determined by HPLC within 24 h. Result: Phentolamine and dopamine did not affect the stability of doxofylline. The pH of solutions affect the stability of phentolamine mesylate and dopamine hydrochloride, which lead them decreased. Conclusion: The mixture of doxofylline injection, phentolamine mesylate injection and dopamine hydrochloride injection in 5% glucose injections is stable in quality within 24h. But they are not stable, when mixed in 0.9% sodium chloride injection.
出处
《中国药师》
CAS
2009年第12期1766-1768,共3页
China Pharmacist