多索茶碱、甲磺酸酚妥拉明及盐酸多巴胺注射液的配伍稳定性

Stability and Compatibility of Doxofylline,Phentolamine Mesilate and Dopamine Hydrochloride Injection in 0.9%Sodium Chloride or 5% Glucose Injection

目的:考察多索茶碱注射液、甲磺酸酚妥拉明注射液及盐酸多巴胺注射液的配伍稳定性。方法:观察及测定3种注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后于室温放置24h内的外观、pH及不溶性微粒,并采用高效液相色谱法测定配伍液中3种主药的含量。结果:多巴胺及酚妥拉明不影响多索茶碱的稳定性,配伍液pH对甲磺酸酚妥拉明、盐酸多巴胺的稳定性影响较大。结论:多索茶碱注射液、甲磺酸酚妥拉明注射液及盐酸多巴胺注射液适以5%葡萄糖注射液作溶媒配伍于24h内使用,不宜与0.9%氯化钠注射液配伍使用。

Objective： To study the compatibility and stability of doxofylline injection, phentolamine mesilate injection and dopamine hydrochloride injection. Method ： The changes in appearance, particles and pH value of the mixture of the two injections in 0.9% sodium chloride injection and 5% glucose injection within 24 h at ambient temperature were observed. The concentrations of the mixture of the three injections in 0.9% sodium chloride injection and 5% glucose injection were determined by HPLC within 24 h. Result： Phentolamine and dopamine did not affect the stability of doxofylline. The pH of solutions affect the stability of phentolamine mesylate and dopamine hydrochloride, which lead them decreased. Conclusion： The mixture of doxofylline injection, phentolamine mesylate injection and dopamine hydrochloride injection in 5% glucose injections is stable in quality within 24h. But they are not stable, when mixed in 0.9% sodium chloride injection.