超声溶栓对血红细胞结构形态的影响

Effects of Thrombolysis by Ultrasound on the Structure of Erythrocyte

应用低频高能超声波消溶全血细胞血栓、探讨超声强度及作用(消融)时间对血红细胞结构形态的影响及其安全剂量阈值。在血栓消溶条件下,用生物显微镜观察血栓细胞结构形态改变,得到了超声强度及作用时间与血栓消融状态下的关系图。结果表明,超声波具有肯定的溶栓作用,该作用与超声强度和消溶时间及细胞结构形态可分为A、B、C三个特征区域,即A区为超声溶栓安全剂量区;B区为相对安全区;C区为不可逆损伤区。研究还发现,超声强度大小及消融时间长短,对血红细胞结构形态有明显影响。声强过大或作用时间过长,均对血红细胞造成不可逆损伤。随着超声强度增加,可加速其消融过程,缩短消融时间。

The effects of the ultrasonic intensity and the effect time on the structure of erythrocyte and the threshold of safe dose have been investigated by using the low-frequency and high power ultrasonic wave to ablate the all blood cells thrombus. The structure of erythrocyte in thrombolysis was evaluated by light microscope under the condition of thrombus ablation. The relationship between the structure of erythrocyte in thrombus and ultrasound intensity and effect time was got. The result showed that the ultrasonic wave did eliminate the thrombus. According to the change of the structure of erythrocyte in thrombus and ultrasound intensity and effect time,the effects of thrombolysis by ultrasound could be divided into three kinds,that is the A,B,C area. The A area was the safe area,the B area was the relatively safe area,and the C area was the unsafe area. The results also showed that the ultrasound intensity and effect time had great impact on the structure of erythrocyte. Greater ultrasound intensity or longer effect time could cause irreversible damage to erythrocyte. The process of the thrombus ablation could be accelerated and the effect time could be shortened with the increase of the ultrasound intensity. So the study of effects of thrombolysis by ultrasound on the structure of erythrocyte and its threshold of safe dose had practical significance.