舍曲林与氯丙嗪治疗强迫症对照研究

Comparative Study of Sertralin and Chlorimine in Treatment of Obsessive-compulsive Disorder

目的比较舍曲林与氯丙咪嗪治疗强迫症的疗效及副反应。方法选择符合诊断标准的强迫症60例,随机分为舍曲林与氯丙咪嗪两组,舍曲林组给予舍曲林50-100m g/d;氯丙咪嗪组给予氯丙咪嗪150-225m g/d,观察8周。结果两组比较疗效无显著差异,舍曲林组第1周末起效,氯丙咪嗪组第4周起效,起效时间两组比较差异显著（P＜0.05）;副反应两组比较舍曲林组小（P＜0.01）。结论舍曲林是一种安全有效的抗强迫症药物。

Objective To explore the curative effect and side effects of sertralin in treatment of obsessive-compusive disorder . Methods Sixty patients with obsessive-compulsive disorder were divided into 2 groups randomly . One group was treated with sertralin at average dose of （50-100）mg/d,and the other group was treated with chlorimipramine at average dose of（150-225） mg/d for a period of 8 weeks. Results There was no significant difference in the curative effect between two groups. The sertralin group took into effect at the end of the Ist week while the group chlorimipramine at the end of the 4th week. The sertralin group had significantly lower side effects than the chlorimpipramine group（P〈0.01）. Conclusion Mirtazapine is effective and safe in treatment of obsessive-compulsive disorder.