宫颈癌周边区淋巴管形态分布与肿瘤转移的关系探讨

The Study of Morphological Distributions of Lymphatic Vessels in Peripheral Areas of Uterine Cervix Cancer and Metastasis

目的观察不同病程人官颈癌周边区淋巴管的形态分布特点,为探讨宫颈癌淋巴道转移机制提供形态学依据。方法将临床手术切除的宫颈癌组织,按癌组织中心区、周边区及正常区取材,采用石蜡切片HE染色光镜观察法、半薄切片光镜观察法和超薄切片电镜观察法,对宫颈癌淋巴管的形态分布和癌组织进行了形态学观察。结果癌细胞已突破基膜并向间质浸润;宫颈癌周边区较正常区淋巴管增多,并可见淋巴管扩张,管壁模糊破损。结论宫颈癌周边区淋巴管增多和形态改变,对肿瘤细胞最终发生淋巴道转移起着重要的作用。

Objective To investigate the metastasis mechanism by observing morphological distributions of lymphie vessels in pe- ripheral areas of the different development of uterine cervix cancer. Methods Cancer tissues from the center, peripheral and normal are- as of uterine cervix cancer respectively were collected. The paraffin sections and semithin sections which were stained with HE were ap- plied to those tissues for exploring the configurations and distributions of lymphic vessels of the cancer under a microscope. And the uhra- thin sections were applied to those tissues for exploring under a electronic microscope. Results Under the microscope, the basement membrane had been destroyed by cancer cell, which continued to infiltrate interstitial tissue. Lymphic vessels were increased and dilated in peripheral areas of uterine cervix cancer than those in normal areas. Moreover, the walls of lymphic vessels were hazy and broken. Con- clusion The increase and morphologic changes of lymphic vessels in peripheral areas of uterine cervix cancer will play an important role in lymphatic metastasis.