非洛地平联合缬沙坦治疗原发性高血压疗效观察

Observation of Curative Effect on Primary Hypertension Treated with Feiodipine in Combination with Valsartan

目的对非洛地平与缬沙坦联合应用治疗高血压的有效性及安全性作出评价。方法将192例原发性高血压患者随机分为3组,分别给予非洛地平、缬沙坦及联合用药进行治疗,疗程均8周,观察治疗前后临床疗效和相关指标的变化情况及不良反应发生率。结果非洛地平组、缬沙坦组与联合用药组总有效率分别为71.9%,75.0%,95.3%。3组中均未发生严重不良事件,安全性指标无异常。结论非洛地平联合缬沙坦治疗原发性高血压优于其中单一药物治疗。

Objective To evaluate the security and validity of Felodipine in combination with Valsartan in treating primary hyperten- sion. Methods 192 cases of patients with primary hypertension were divided into 3 groups randomly and treated by Felodipine, Valsar- tan, Felodipine in combination with Valsartan respectively. All course of treatment was 8 weeks. The clinical curative effect and variation of relative index and incidence rate of adverse reactions at pretherapy and post - therapy were observe. Results Effective rate of Felodipine, Valsartan and Felodipine in combination with Valsartan group was 71.9% ,75.0% ,95.3% respectively. No serious adverse event in 3 groups happened and secure indexs were normal. Conclusion Felodipine in combination with Valsartan in treating primary hypertension is predominant over Felodipine, Valsartan lonely.