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基质金属蛋白酶及其抑制物与肿瘤转移研究进展 被引量:1

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摘要 基质金属蛋白酶是一个大家族,因其需要Ca^2+、Zn^2+等金属离子作为辅助因子而得名,其家族成员具有相似的结构,一般由5个功能不同的结构域组成:①疏水信号肽序列;②前肽区,主要作用是保持酶原的稳定。当该区域被外源性酶切断后,MMPs酶原被激活;③催化活性区,有锌离子结合位点.
出处 《医学研究杂志》 2009年第11期113-114,共2页 Journal of Medical Research
基金 湖南省教育厅高等学校科研基金资助项目(D6C074)
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