子痫前期患者外周血和绒毛间隙血样中可溶性endoglin水平研究

Levels of soluble endoglin in peripheral blood and intervillous space blood of patients with preeclampsia

目的研究子痫前期患者外周血和绒毛间隙血样中可溶性endoglin(sEng)水平及其与患者临床表现的相关性。方法采用ELISA法检测22例子痫前期患者(轻度10例,重度12例)外周血和绒毛间隙血样sEng水平,分析其与患者血压、24h尿蛋白定量及新生儿体质量的相关性。以22名正常妊娠妇女作为对照组。结果子痫前期组和对照组sEng水平,在外周血分别为(31.89±8.80)ng/mL和(5.24±1.60)ng/mL,在绒毛间隙血样分别为(37.74±7.12)ng/mL和(6.63±1.76)ng/mL,两组比较差异均有统计学意义(P<0.01)。在子痫前期组内,重度患者外周血和绒毛间隙血样sEng水平均明显高于轻度患者(P<0.01)。相关分析表明,子痫前期患者外周血sEng水平与绒毛间隙血样sEng水平呈显著正相关(r=0.876,P<0.01);两者与患者血压均无明显相关性(P>0.05),与24h尿蛋白定量均呈显著正相关(r=0.729,r=0.743,均P<0.01),与新生儿体质量均呈显著负相关(r=-0.736,r=-0.707,均P<0.01)。结论子痫前期患者外周血和绒毛间隙血样sEng水平显著高于正常妊娠妇女,且与患者病情严重程度显著相关。

Objective To study the levels of soluble endoglin （sEng） in peripheral blood and intervillous space blood of patients with preeclampsia,and analyse the correlation between levels of sEng and clinical performance. Methods Levels of sEng in peripheral blood and intervillous space blood of 22 patients with preeclampsia （preeclampsia group,12 cases of severe preeclampsia and 10 cases of mild preeclampsia） were detected by ELISA,and the correlation between levels of sEng and blood pressure,24 h urine protein and fetal birth weight was analysed. Twenty-two normal pregnant women were served as control group. Results The sEng levels in peripheral blood and intervillous space blood of preeclampsia group were significantly higher than those of control group ／[（31.89±8.80） ng/mL vs （5.24±1.60） ng/mL,P 0.01; （37.74±7.12） ng/mL vs （6.63±1.76） ng/mL,P 0.01／]. In preeclampsia group,the sEng levels in peripheral blood and intervillous space blood of severe preeclampsia were significantly higher than those of mild preeclampsia （ P 0.01）. In preeclampsia group,the sEng level in peripheral blood was significantly correlated with that in intervillous space blood of preeclampsia group （ r =0.876,P 0.01）,neither was significantly correlated with blood pressure （ P 0.05）,both were significantly correlated with 24 h urine protein （ r =0.729,P 0.01; r =0.743,P 0.01）,and both were significantly correlated with fetal birth weight （ r =-0.736,P 0.01; r =-0.707,P 0.01）. Conclusion Levels of sEng in peripheral blood and intervillous space blood of patients with preeclampsia are significantly higher than those of normal pregnant women,and the levels of sEng are significantly correlated with the clinical performance of preeclampsia.