几种通草及小通草的抗炎、解热、利尿作用的实验研究

Experimental Studies on Anti inflammatory,Antipyretic and Diuretic Effects of Several Species of Tongcao and Xiao tongcao

目的：观察、比较３种通草类药材（通脱木、盘叶掌叶树、罗伞）和７种小通草类药材（喜马山旌节花、西南绣球①，②、棣棠花、穗序鹅掌柴、青荚叶、中国旌节花）的抗炎、解热作用及３种小通草药材（喜马山旌节花、西南绣球②、中国旌节花）的利尿作用，以期为该类药材的功效和临床应用、品种整理和质量研究提供药理学依据。方法：采用角叉菜胶致大鼠足肿胀、啤酒酵母（或角叉菜胶）致大鼠发热模型及大鼠代谢笼法等药理实验方法，观察比较不同药材水煎剂（８，４ｇ／ｋｇ）灌胃给予大鼠后的抗炎、解热和利尿作用。结果：３种通草和７种小通草药材对大鼠角叉菜胶性足肿胀有不同程度的抑制作用，对啤酒酵母（或角叉菜胶）所致的大鼠发热模型表现出不同程度的解热作用，其中通草类药材中通脱木、盘叶掌叶树抗炎、解热作用为优；７种小通草类药材中喜马山旌节花和穗序鹅掌柴抗炎作用较强。３种小通草药材（喜马山旌节花、西南绣球②、中国旌节花）具有明显的利尿作用。结论：结果表明不同品种的通草和小通草类药材均具有不同程度的抗炎、解热和利尿作用，为该类药材的功效和临床应用。

Objective:To observe and compare the anti inflammatory,antipyretic and diuretic effects of three kinds of Tongcao(Tongtuomu,Panyezhangyeshu and Luosan)and seven kinds of Xiao tongcao(Ximashanjinjiehua,Xinanxiuqiu①②,Ditanghua,Suixuezhangcai,Qingjiaye and Zhongguo jinjiehua).Method:Decoctions prepared from the above kinds of Tongcao and Xiao tongcao crude drugs were given to rats at dosages of 8g/kg and 4g/kg by ig.Pharmacological actionswere observed by means of carrageenan induced swelling paws,fever models induced by beeryeast or carrageenan and metabolic cage method in rats.Result:All the experimental decoctions could inhibit carrageenan induced swelling of rat paws in different degrees and exerted anti pyretic effect on rat fever models induced by beeryeast or carrageenan.Three kinds of Xiaotongcao(Ximashanjingjiehua,Xinanxiuqiu②,Zhongguojinjiehua)had obvious diuretic effect on rats.Conclusion:Decoctions of different species of Tongcao and Xiao tongcao all have anti inflammatory,antipyretic and diuretic effects,thus providing some pharmacologic basis for the efficacy assay,clinical application,species collation and quality study of Tongcao and Xiao tongcao.