治疗根性神经痛硬膜外注射曲安缩松A的药代动力学研究与临床评价

Pharmacokinetics and clinical evaluation of epidural triamcinolone for treatment of radicular neuralgia

目的:对根性神经痛病人硬膜外注射曲安缩松A进行药代动力学研究及临床评价。方法:6例根性神经痛病人应用高效液相色谱法测定硬膜外注射TA的血药浓度及药代动力学分析。结果:间隔一周注射40mgTA的药代动力学参数均无显著变化(P>0.05)。结论:TA吸收速率和消除半衰期较慢,间隔一周硬膜外注射40mg TA可避免体内药物蓄积引起的不良反应。

Objective: To investigate pharmacokinetics of epidural triamcinolone A in patients with radicular neuralgia. Method: Serum concentrations were determined with high-performance liquid chromatography in patients with radicular neuralgia who received two epidural administrations of triamcinolone A 40mg at one week interval. Result: The pharmacokintic parameters values didn't show great differences between both administrations (P>0.05). Conclusion: With slow absorption rate and long half life of elimination, the epidural administration at one week interval can avoid the accumulation of triamcinolone A.