七氟醚和硝普钠控制性降压对犬血液动力学影响的对比研究

Hemodynamic effects of induced hypotension with sevoflurane or nitroprusside

目的:比较七氟醚和硝普钠控制性降压对犬血液动力学的影响。方法:将14只杂种犬随机分为七氟醚组和硝普钠组,吸入七氟醚或静滴硝普钠,使MAP降至8kPa,维持30分钟后停药。持续监测MAP、HR、CO、CVP、SV和SVR等指标。结果:在控制性降压期间,七氟醚组和硝普钠组CO分别减少30.7%和21.6%;七氟醚组HR明显减慢(P<0.01),而硝普钠组则不明显;硝普钠和七氟醚均降低SVR,且硝普钠更甚。停药后30分钟,两组SVR显著增加,MAP同步上升且超过基础值水平,而CO仍处于降压期的低水平。结论;与硝普钠相比,七氟醚对循环有抑制作用,但用于控制性降压仍安全有效。

Objective:To compare the effects of induced hypotensions with sevoflurane and nitroprusside on hemodynamics in dogs. Method:Fourteen mongrel dogs were randomly divided into sevoflurane group and nitroprusside group. After experimental preparation,the MAP was decreased to 8kPa and was kept for 30min either with sevoflurane inhalation or with nitroprusside infusion. MAP, HR,CO,CVP,SV and SVR wrer monitored continuously. Result: During induced hypotension, CO in sevoflurane and nitroprusside groups decreased by 30.7% and 21.6% respectively; HR decreased significantly in sevoflurane group, but not in nitroprusside group; SVR in both groups showed reduction, but more pronounced in nitroprusside group. However,after the termination of sevoflurane or nitroprusside, MAP elevated over baseline with the significant increase of SVR,and CO remaining low. Conclusion:As compared with nitroprusside, sevoflurane has inhibitory effect on circulation,yet it is still efficient to induced hypotension.