依那西普治疗类风湿性关节炎40例疗效观察

Treatment of Rheumatoid Arthritis with Etanercept:Clinical Observation of 40 Cases

目的观察依那西普治疗类风湿性关节炎(RA)的疗效及安全性。方法76例RA患者随机分为两组,对照组36例给予甲氨蝶呤和硫酸羟氯喹,治疗组40例应用依那西普,两组疗程均为3个月。结果治疗组总有效率显著高于对照组(P<0.05),在关节疼痛数、关节压痛积分、关节肿胀积分、晨僵时间及20m步行时间等方面均与用药前有显著差异(P<0.05或P<0.01),治疗组不良反应发生率显著低于对照组(P<0.05)。结论依那西普治疗RA疗效优于传统的甲氨蝶呤和羟氯喹,且不良反应少而轻微,安全性好。

Objective To observe the curative effect and safety in the treatment of rheumatoid arthritis（RA）with etanercept. Methods We divided 76 patients with rheumatoid arthritis randomly into two groups：control group and treatment group, and the control group（ 36 cases）was given methotrexate sulfuric acid and hydroxychloroquine for 3 months and the treatment group（40 cases）was given etanercept for the same time. Results The total effective rate of the treatment group was significantly higher than that of control group（P〈0.05 ）. There was a significant difference in the number of joint pain,joint tenderness score,joint swelling score, morning stiffness time, 20m walking time, etc.after treatment compared with pre-therapy（P〈0.05 or P〈0.01 ）, The incidence of adverse reactions in the treatment group was significantly lower than that of the control group（P〈0.05）, Conclusion Etanercept in the treatment of rheumatoid arthritis is superior to traditional methotrexate and hydroxychloroquine, with few adverse reactions and good safety.