小于胎龄儿C肽和胰岛素样生长因子Ⅰ水平变化及其意义

Cord and peripheral blood C peptide and insulin like growth factor Ⅰ levels and their importances in small for gestational age neonates

目的探讨Ｃ肽（ＣＰ）和胰岛素样生长因子Ⅰ（ＩＧＦＩ）水平在小于胎龄（ＳＧＡ）儿的变化及其意义。方法利用放射免疫分析法测定了４８例ＳＧＡ儿脐血清和其中的３７例ＳＧＡ儿生后一周内外周血ＣＰ和ＩＧＦⅠ。结果ＳＧＡ儿脐血ＣＰ和ＩＧＦＩ水平低于适于胎龄（ＡＧＡ）儿水平，且ＳＧＡ儿的不良生长程度越重，ＣＰ和ＩＧＦⅠ水平越低，生后一周内，重度ＳＧＡ儿外周血ＣＰ和ＩＧＦⅠ仍维持低水平，而轻度ＳＧＡ儿ＣＰ和ＩＧＦⅠ则上升至ＡＧＡ儿水平。结论ＳＧＡ儿的不良生长与低胰岛素和ＩＧＦⅠ水平有关。

Objective Determining cord and peripheral blood C peptide (CP) and insulin like growth factor Ⅰ (IGF Ⅰ) concentrations, and making an inquiry into their importance in the small for gestational age (SGA) neonates. Methods CP and IGF Ⅰ concentrations in the cord blood of 48 term SGA neonates and in the peripheral blood of 37 term SGA infants with postnatal age of 1 7 days were determined by radioimmunoassay. Results Cord blood CP and IGF Ⅰ levels in SGA neonates were lower than those of appropriate for gestational age (AGA) neonates. The severer the intrauterine growth retardation was, the lower the cord blood CP and IGF Ⅰ levels. In postnatal age of 1 7 days, the serious SGA infants still had low CP and IGF Ⅰ levels, whereas in the light SGA infants, their CP reached the level of AGA infants; their IGF Ⅰ level exceeded that of AGA infants. Conclusion Growth retardation in SGA infants is associated with low insulin and IGF Ⅰ concentrations.