CD44变异型在支气管粘膜上皮癌变过程中的表达及其意义

Expression of CD44 variant isoforms in bronchial precancerous lesions

目的 探讨CD44变异型 (以下简称CD44v)表达在肺鳞癌发生中的作用。方法 应用免疫组织化学方法检测 3 4例肺鳞癌及其癌前病变标本中CD44v的表达 ,分析CD44v在肺鳞癌发生过程中出现表达的时间和频率。结果 癌旁正常支气管上皮细胞未见CD44v表达 ,在鳞状化生的支气管上皮细胞、轻→中→重度不典型增生、原位癌、浸润癌中 ,CD44v表达的阳性率逐渐升高。结论 本研究结果表明 ,CD44v可作为判断肺鳞癌发生可能性的标记物 ,在肺鳞癌的早期诊断中具有重要意义。

Objective To explore the role of CD44 variant isoforms (CD44v) expression on oncogenesis of squamous cell carcinoma of the lung.Methods CD44v expression was detected by immunohistochemical analysis in cancer tissues and precancerous lesion samples of 34 patients with squamous cell carcinoma of the lung and its expression time and frequency were studied during carcinogenesis of lung cancer.Results Membrane CD44v were present in 0 of 12 normal mucosae adjacent to the cancers, 2 of 14 squamous metaplasias, 3 of 13 mild dysplasias, 5 of 17 moderate dysplasias, 12 of 21 severe dysplasias, 5 of 9 carcinomas in situ, and 21 of 34 invasive tumors. With the progress of bronchial lesions from mild dysplasia to severe dysplasia and to carcinoma in situ and invasive carcinoma, the positive rate of CD44v expression increased gradually.Conclusion The research indicates that CD44v expression is likely to be an usable marker to judge the probability of squamous cell carcinoma of the lung and that routine assessment of CD44v expression may be valuable for the early diagnosis of squamous cell carcinoma of the lung.