检测非小细胞肺癌IL-2R的临床意义

Clinical significance of detection of IL-2R for non small cell lung cancer

目的 探讨检测血清可溶性白细胞介素 2受体 (SIL 2R)和肺癌组织IL 2R表达在非小细胞肺癌中的临床意义。方法 采用双抗体夹心ELISA法和免疫组化法检测 42例非小细胞肺癌患者血清和肺癌组织中IL 2R水平。结果 肺癌患者血清SIL 2R水平显著高于正常人 (P <0 .0 5 ) ,Ⅲ、Ⅳ期肺癌患者血清SIL 2R水平显著高于Ⅰ、Ⅱ期 (P <0 .0 5 ) ,但血清SIL 2R水平与肺癌组织学类型无明显关系(P >0 .0 5 )。肺癌组织中IL 2R水平显著高于正常肺组织 (P <0 .0 5 ) ,Ⅲ、Ⅳ期肺癌组织中IL 2R水平显著高于Ⅰ、Ⅱ期 (P <0 .0 5 ) ,不同组织学类型肺癌组织中IL 2R水平无显著差异 (P >0 .0 5 )。结论 检测肺癌患者血清SIL 2R和肺癌组织IL

Objective To explore the clinical significance of SIL 2R of serum and IL 2R expression of cancer tissue in non small cell lung cancer. Methods SIL 2R levels in the serum and IL 2R expression in cancer tissues were detected in 42 non small cell lung cancer by ELISA and immunohistochemistry respectively.Results Serum SIL 2R level was significantly higher in lung cancer group than that in normal control group (P<0.05) , and significantly higher in stage Ⅲ,Ⅳ disease than that in stage Ⅰ,Ⅱ disease (P<0.05), but it was not associated with histological classification of the cancer (P>0.05).IL 2R expression was significantly higher in lung cancer tissue than that in normal lung tissue (P<0.05) and was significantly higher in stage Ⅲ,Ⅳ cancer than that in stage Ⅰ,Ⅱ cancer (P<0.05). But it was not related to cancer types (P>0.05) .Conclusion The results suggest that detection of serum SIL 2R and IL 2R expression of the cancer tissue might be useful to predict stages of cancer and monitor the prognosis of patients with lung cancer.