放疗并用榄香烯治疗脑转移癌近期疗效观察

Observation on short-term efficacy of radiotherapy combined with elemene in treatment of metastatic brain cancers

目的比较放疗同时加榄香烯与单纯放疗治疗脑转移癌的近期疗效。方法对脑转移癌患者55例进行回顾性分析,其中综合治疗(放射治疗+榄香烯)27例,单纯放疗28例。采用常规分割照射全脑总剂量40 Gy/4.5周。给药方法放疗同时每日经中心静脉给榄香烯400 mg。结果放疗开始后两周内综合治疗临床症状缓解率(77.8%)明显优于单纯放疗(53.6%);两组肿瘤消退率(CR)分别为70.4%和35.7%,差异有显著性(P<0.05)。综合治疗患者的骨髓抑制少,程度轻;单纯放疗的患者骨髓抑制多,程度重。结论榄香烯对脑转移癌放疗有协同作用,可以促进肿瘤消退,同时能减轻放疗对骨髓的抑制作用。

Objective To compare the short-term efficacy of radiotherapy combined with elemene and radiotherapy alone in treatment of the brain metastatic cancer.Methods Fifty-five cases of brain metastatic cancer were retrospectively analyzed.Twenty-seven patients were treated with combined treatment（radiotherapy ＋ elemene）,and 28 patients with radiotherapy alone.The total radiation dose of the whole brain was 40Gy/4.5 weeks.Elemene 400mg was given by central vein everyday from the beginning of radiotherapy. Results Two weeks after the beginning of radiotherapy, the clinical remission rate of the combined treatment group （77.8%） was significantly highter than that of the group treated with radiotherapy alone （ 53.6% ）. The complete remission （CR） rate in the two groups were 70. 4% and 35.7%, the difference was significant （ P 〈 0. 05 ）. The myelosuppression in combined treatment group was lower in incidence and lighter; while in radiotherapy alone group was higher in incidence and heavier. Conclusion Elemene has synergistic effect on radiotherapy in the brain metastatic cancer, and can not only promote tumor regression but al- so reduce the suppression of bone marrow.