摘要
目的研究结直肠癌缺失基因在宫颈癌中表达的，临床意义及其与宫颈癌发生发展的关系。方法应用免疫组织化学的方法检测结直肠癌缺失基因在宫颈癌、宫颈上皮内瘤变Ⅱ～Ⅲ、慢性宫颈炎组织中的表达情况，并分析其与宫颈癌发生发展的关系。结果结直肠癌缺失基因在宫颈癌组织中表达的阳性率为22．7％（5／22），明显低于宫颈上皮内瘤变Ⅱ～Ⅲ组织中表达的阳性率60．0％（6／10）和慢性宫颈炎组织中表达的阳性率80．0％（16／20），χ^2值分别为1．05和12．04，均P〈0．05。结论结直肠癌缺失基因表达降低或缺失在宫颈癌的发生发展过程中有一定关系，免疫组化法检测结直肠癌缺失基因的表达对宫颈癌的预后评估具有重要临床意义.
Objective To explore clinical significance of expression of DCC in cervical carcinoma and its relationship with occurrence and development of cervical cancer. Methods The expression of DCC in tissues of cervical cancer, CIN Ⅱ -Ⅲ and chronic cervicitis was detected by using immunohistochemical method （SP method） and its relationship with occurrence and development of cervical canc, er was analyzed. Results The positive expression rate of DCC protein in cervical carcinoma was 22.7% （5/22） , which was significantly lower than 60.0% （6/10） of that in tissues of CINⅡ -Ⅲ and 80.0% （16/20） of that in tissues of chronic cervicitis （X2 = 11.05, 12.04 respectively, both P 〈 0.05）. Conclusion There are some associations between decreased or absent expression of DCC and occurrence and development of cervical cancer. The expression of DCC detected by immunohistochemical SP method is of important clinical significance for judging prognosis of cervical cancer.
出处
《中国妇幼健康研究》
2009年第6期643-645,共3页
Chinese Journal of Woman and Child Health Research
基金
湖南省教育厅科学研究项目（07C059）
