免疫球蛋白佐治毛细支气管炎126例分析

A clinical analysis of therapeutic effect of human immunoglobulin for 126 cases of bronchiolitis

目的观察婴儿毛细支气管炎应用静脉免疫球蛋白的临床疗效。方法将126例毛细支气管炎患儿分为两组，治疗组在对照组常规治疗的基础上加用静脉免疫球蛋白400mg·kg^-1·d^-1，连用3天，观察疗效。结果两组治疗有效率比较差异有统计学意义χ^2=4．76，P〈0．05）；治疗组与对照组在紫绀、喘憋、咳嗽、哮喘音消失时间以及平均住院时间上比较，差异有统计学意义（t值分别为6．10、4．21、4．84、5．02、3．13，均P〈0．01）。结论静脉免疫球蛋白对毛细支气管炎患儿具有良好的抗感染和免疫调节作用。

Objective To investigate theapeutic effect of intravenous administration of human immunoglobulin for infants with bronchiolitis. Methods 126 infants with bronchiolitis were randomly divided into two groups ： treatment group and control group. On the basis of routine therapy as did in the control group, these infants in the treatment group were administered intravenously 400mg· kg^-1 . d^- 1 of human immunoglobulin（IG） for 3 consecutive days, and the therapeutic effects were observed. Results Between the two groups, there was a significant difference in effective rate （χ^2 = 4.76, P 〈 0.05 ）. Also, in disapearence times of symptoms and signs such as cyanosis, gasping, coughing and wheezing tale and average length of hospital stay there were significant differences between the two groups（ t = 6.10, 4.21, 4.84, 5.02, 3.13 respectively, all P 〈 0.01 ）. Conclusion Intravenous administration of IG （IVIG） exerts significant antibiotic and immune regulation effects for those infants with bronchiolitis.