4种化疗方案治疗老年晚期非小细胞肺癌的最小成本分析

Cost-Minimization Analysis of 4 Chemotherapeutic Schemes for Advanced Non-small Cell Lung Cancer in Elderly Patients

目的:探讨4种化疗方案治疗老年晚期非小细胞肺癌的经济学效果。方法:92例老年晚期非小细胞肺癌患者,根据不同治疗方案随机分为GP、NP、PC、TP4组,运用药物经济学最小成本分析法对4种治疗方案进行回顾性分析、评价。结果:GP、NP、PC、TP4种治疗方案成本分别为10820.69、5864.54、7595.57、7774.64元(P<0.05),有效率分别为35.00%、34.48%、36.36%、38.10%(P>0.05)。不良反应为不同程度的骨髓抑制和消化道反应等,经对症治疗可痊愈。结论:NP方案在4种方案的最小成本分析中最显优势。

OBJECTIVE： To investigate the pharmacoeconomic efficacy of four chemotherapeutic schemes for advanced non - small cell lung cancer in elderly patients. METHODS： 92 elderly patients with advanced non - small cell lung cancer were randomly divided into four groups： GP, NP, PC, and TP groups. The pharmacoeconomic efficacy of the four groups was an- alyzed and evaluated retrospectively using the cost - minimization analysis in pharmacoeconomics. RESULTS： The costs of GP, NP, PC, and TP schemes were 10 820.69 yuan, 5 864.54 yuan, 7 595.57 yuan, and 7 774.64 yuan, respectively（P〈 0.05）, and the effective rates of four schemes were 35.00%, 34.48%, 36.36%, and 38.10% （P〉 0.05）, respectively. The adverse drug reactions were characterized by different degree of myelosuppression and gastrointestinal reactions, all were cured on symptomatic treatment. CONCLUSION ： The cost - minimization analysis showed that NP scheme is the optimal one of the four schemes.