铜绿假单胞菌耐药率与常用抗菌药物用量的相关性分析

Correlation Between Consumption Amount of Commonly Used Antimicrobial Agents and Antibiotic Resistance Rate of Pseudomonas Aeruginosa

目的:分析我院铜绿假单胞菌(PA)的耐药率与抗菌药物用量之间的相关性,为临床合理应用抗菌药物提供参考。方法:回顾性分析我院2001～2007年PA的耐药率和具有抗PA活性的抗菌药物使用量,并采用SPSS12.0统计软件分析二者之间的相关性。结果:PA对各种具有抗PA活性的抗菌药物的耐药率大体呈逐年上升趋势。所调查药物用药频度的变化呈多样化。PA的耐药率与哌拉西林/他唑巴坦、美罗培南、环丙沙星和莫西沙星的用量之间呈正相关性。结论:我院分离的PA的耐药率呈逐年上升趋势,与多种抗菌药物使用量之间存在相关性。

OBJECTIVE： To analyze the correlation between the consumption amount of antimicrobial agents and antibi- otic resistance rate of Pseudomonas aeruginosa （PA） in our hospital for clinical reference of rational use of antimicrobial agents. METHODS： The antibiotic resistance rate of PA and the consumption amount of anti -PA antimicrobial agents in our hospital from 2001 to 2007 were retrospectively analyzed. The correlation between the two was statistical analyzed by using SPSS12.0. RESULTS： The antibiotic resistance rate of PA increased year by year. However, the DDDs of the antimicrobial agents as- sumed diversified change. The antibiotic resistance rate of PA was positively correlated with the consumption amount of piperacillin/ tazobactam（TZP）, meropenem（MPM）, ciprofloxacin（ClP） and moxifloxacin（MOX） . CONCLUSION ： The an- tibiotic resistance rate of PA showed an increasing trend in our hospital and which was positively correlated with the con- sumption sum of multi - kind of antimicrobial agents.