我院332例药品不良反应报告分析

Adverse Drug Reactions in Our Hospital:Analysis of 332 Cases

目的:了解我院发生药品不良反应(ADR)的情况、特征及影响因素。方法:采用描述性研究方法,对我院2005年1月～2008年9月收集的332例ADR报告进行统计、分析。结果:涉及ADR的药品共127个,发生频率排在前3位的是抗感染药、解热镇痛药及心血管药;静脉与口服途径给药比例相当,各为148、140例;ADR的主要临床表现以皮肤及其附件损害为主,有208例(62.65%);因重复用药导致因果关系评定为肯定的例数较多,有54例。结论:临床应重视ADR监测与报告,定期分析报告数据,为临床及时提供药品安全信息,以减少或避免ADR的重复发生。

OBJECTIVE： To investigate the status, characteristics and influencing factors of the adverse drug reactions （ADR） occurred in our hospital. METHODS： By a descriptive study, the ADR reports of 332 cases collected from Jan. 2005 to Sep. 2008 in our hospital were analyzed statistically. RESULTS： 127 kinds of drugs were involved in the 332 ADR cases, leading the first 3 places in terms of ADR incidences were anti- infection agents, antipyretic analgesics and drugs for cardio- vascular system; 148 cases were induced via intravenous route versus 140 via oral route; the ADR of 208 （62.65%） appeared mainly as lesions of skin and its appendants; 54 ADR cases were regarded as caused by repeated medication. CONCLUSION： Great importance should be attached to ADR monitoring and reporting by regular analyzing reporting data for references of clinical medication safety so as to reduce or avoid the repeated occurrence of ADR.