对机械性心脏瓣膜置换患者应用华法林进行药学服务的重要性及相关问题

Importance and the Related Issues of Pharmaceutical Care for Application of Warfarin in Patients with Mechanical Valve Replacement

目的:减少机械性心脏瓣膜置换术后患者抗凝治疗的并发症。方法:通过分析影响华法林抗凝作用的因素及患者在华法林抗凝治疗中容易出现的问题开展药学服务,指导其规范使用抗凝药华法林。结果与结论:影响华法林抗凝作用的因素较多,药师应积极开展合理有效的药学服务以减少华法林抗凝治疗中出血和血栓等并发症的发生,避免患者因药物使用而造成的身体损害,对提高患者术后生活质量具有重要意义。

OBJECTIVE： To reduce the incidence of complications in anticoagulant treatment for patients with mechanical heart valve replacement. METHODS： The factors affecting the anticoagulative efficacy of warfarin were analyzed, and phar- maceutical care was performed for patients to provide them with guidance about the standard use of warfarin in case of the problems likely occurred during the anticoagulant treatment. RESULTS ＆ CONCLUSION： The anticoagulative efficacy of warfarin was influenced by many factors. It is important for pharmacists to carry out active, reasonable and effective phar- maceutical care so as to reduce the incidences of bleeding and thrombus during anticoagulant treatment, avoid drug - induced physical lesions and improve patients＇ quality of life after surgery.