辅酶Q_9的研究与探讨

文章介绍了一种半合成法制备辅酶Q的路线,即由芳香性主环Q与有广阔开发前景的天然提取物茄尼醇进行加90合,制取心血管新药辅酶Q9。此法成本低,可以大量合成,为进一步进行药理研究提供基础。并概述了辅酶Q9(包括辅酶Qn一类化合物)的功效及其应用情况,对其进一步的开发应用进行了展望。

An effective methodology has been developed leading to the semi-synthesis of Coenzyme Q9.Coupling of aromatic ring Q0 and highly prospective natural product solanesol produced the new cadiovascular medicine-Coenzyme Q9.This low cost large-scale synthesis would be useful in additional efforts on its pharmacological research.The application and medicinal usage of Coenzyme Q9 （including Qns）were summarized in this article,and the prospect of the further explorer work on it as well.