摘要
Objective： We investigated the relationship between lymphangiogenesis, angiogenesis and cell proliferation in gastric cancer. Methods： We observed the central cancer tissues and the peritumoral tissues of 75 patients with gastric carcinoma by immunohistochemistry. Using D2-40, VEGFR-C and VEGFR-3 detected the microlymphatic density （MLD）, CD34 and CD31 detected the microvessel density （MVD）. The proliferation of the cells was labeled by Ki-67. Results： There were a few atresic streak lymphatic vessels in the central cancer tissues, but in the peritumoral tissues lymphatic increased and dilated, it appears adenoid structure. LMVD in the gastric central area （33.7 ± 14.7） decreased significantly than in the peripheral zone （61.8 ± 22.6; P 〈 0.01）. The differences in the distribution and amount of microvessels were similar to lymphatic vessels. The central area of gastric cancer has a small amount of the distribution of focal Ki-67 positive tumor cells, while around the central area there were a large number of Ki-67 positive tumor cells, especially in one low power field （× 10）. Gastric central area of the Ki-67 positive cells in gastric central area （49.5%） were significant decreasing than in the cancer peripheral zone （73.2%; P 〈 0.05）. Conclusion： The mainly distribution of the neonatal lymphatic vessels, blood vessels and Ki-67 positive carcinoma in gastric cancer is anterior border of carcinoma tissues, especially in one low power field （x 10）. The MLD, MVD and Ki-67 positive carcinoma might be an important index for the prognosis of gastric carcinoma. The more lymphatic microvessel, microvessel and Ki-67 positive carcinoma in the peritumoral tissues, the poorer prognosis, vice versa.
