mTOR信号通路与胰岛素抵抗的关系及运动的影响

mTOR signaling pathway in the development of insulin resistance and the effects of exercise

哺乳动物雷帕霉素靶蛋白（mTOR）是细胞内感受细胞外营养、能量水平以及生长因子等信号变化的一种丝／苏氨酸蛋白激酶，参与调节细胞生长、分化、增殖以及蛋白质合成等过程，并且与胰岛素抵抗（IR）的发生、发展关系密切。本文对mTOR／S6K1信号通路的调控机制与IR发生、发展过程的关系，以及运动对mTOR信号通路的影响加以综述，以期为探寻合理的运动手段以及药物作用靶点作为治疗由细胞代谢紊乱引起的IR、2型糖尿病等代谢性疾病提供理论依据。

The mammalian target of rapamycin （mTOR） is one of the Ser/Thr protein kinases that functions as a key integrator of signaling from nutrients, energy and growth factors, roTOR integrates extensive biological process including cell growth,proliferation and protein synthesis ete, and has a close relationship with the development of insulin resistance（IR）. This article summarized the recent studies about the regula- tion mechanism of mTOR/S6K1 and its relationship with the development of IR, and the effects of exercise on roTOR signaling pathway, inorder to provide theory basis for searching possible exercise forms and pharma- ceutical targets in treating the metabolic diseases like IR and type 2 diabetes which are induced by disturb- ance of cell metabolism.