期刊文献+

非小细胞肺癌外周血微转移的研究现状 被引量:1

The Research Status of Micrometastasis of Non-small Cell Lung Cancer in Peripheral Blood
下载PDF
导出
摘要 非小细胞肺癌(NSCLC)是常见的恶性肿瘤,治疗效果不佳,许多在术中证实为淋巴结阴性的患者仍在术后出现复发或转移的现象,这可能是常规的病理手段无法发现的微转移病灶所致。目前免疫组织化学和聚合酶链反应等技术已经应用于外周血、骨髓和肿瘤附近淋巴结中微转移灶的检测,然而微转移的检测指标的选择和临床意义仍未达成共识。 Non-small cell lung cancer(NSCLC) is a common malignancy, with poor efficacy. Many patients who are proved to have no lymph node metastasis still suffer relapse after operation. The reason of this phenomenon may be that the means of conventional pathology cannot find micrometastatisis of the disease. At present,the immunocytochemistry and PCR methods were used to detect micrometastasis in the peripheral blood, bone marrow and lymph node. However, the selection and the clinical significance of micrometastasis index have not yet reached a consensus.
出处 《医学综述》 2009年第23期3565-3569,共5页 Medical Recapitulate
关键词 非小细胞肺癌 微转移 外周血 Non-small cell lung cancer Micrometastasis Peripheral blood
  • 相关文献

参考文献30

  • 1Shibuya K, Hiraoka M. Radiation therapy for lung cancer[ J]. Gan to Kagaku Ryoho ,2007,34 (4) :544-549.
  • 2Coello MC, Luketich JD, Litle VR, et al. Prognostic significance of micrometastasis in non-small-cell lung cancer[J]. Clin Lung Cancer,2004,5 (4) :214-225.
  • 3Scagliotti G, Novello S. Adjuvant chemotherapy after complete resection for early stage NSCLC [ J ]. Lung Cancer, 2003,42 (Suppl 1 ) :$47-51.
  • 4Hermanek P, Hurter RV, Sobin LH, et al. Classification of isolated tumor cells and micrometastasis [ J ]. Cancer, 1999, 86 ( 12 ) : 2688-2673.
  • 5刘小青,任宏轩.非小细胞肺癌骨髓微转移研究现状[J].肿瘤基础与临床,2007,20(5):459-460. 被引量:2
  • 6Park BJ, Altorki NK. Diagnosis and management of early lung cancer [ J ]. Surg Clin North Am, 2002,82 ( 3 ) :457 -476.
  • 7Buccheri G. Tumor markers : clinical meaning and use [M]// Brambilla C, Brambilla E (eds). Lung tumors. New York : Marcel Dekker Inc, 1999:435-452.
  • 8Buccheri G, Ferogno D. The tissue polypeptide antigen serum test in the preoperative evaluation of non-small cell lung cancer. Diagnostic yield and comparison with conventional staging methods[J]. Chest, 1995,107 (2) :471-476.
  • 9Passlick B, Izbicji JR, Nubuscbok B, et al. lmmunohistochemical assessment of individual tumor cells in lymph nodes of patients with non-small cell lung cancer [J]. Clin Oncol, 1994, 12 ( 9 ) : 1827-1832.
  • 10丁昌平,曹春梅,韩芳,柳健,张敏,顾军,殷旭东.肺癌外周血CK19mRNA表达的临床意义[J].中国卫生检验杂志,2007,17(5):868-870. 被引量:2

二级参考文献66

共引文献42

同被引文献18

  • 1牛中喜,郭金成,汪良骏,朱金如,李树军.流式细胞术检测肺癌患者外周血微转移的探讨[J].现代肿瘤医学,2006,14(8):950-951. 被引量:2
  • 2仲崇俊,蒋庚西,陶国华,王永旺.非小细胞肺癌患者围手术期外周血中肺表面活性蛋白D mRNA的表达及临床意义[J].中国肿瘤,2007,16(3):196-198. 被引量:2
  • 3Gold P.Freedman SO.Specific carcinoembryonic antigens of the human digestive system[J].Exp Med,1965(122):467-481.
  • 4Betz C,Papadopoulos T,Buchwald J,et al.Surfactant protein gene expression in metastatic and micrometastatic pulmonary and other non-small-cell lung carcinomas:detection by reverse transcrip tasepelymerase chain reaction[J].Cancer Res,1995,55(19):4283-4286.
  • 5Chen JT,Cheng YW,Chou MC,et al.The correlation between aberrant connexin 43 mRNA expression induced by promoter methylation and nodld micrometastasis in non-small-cell lung cancer[J].ClinCancerRes,2003,9(11):4200-4204.
  • 6Buccheri G.Tumor markers:clinical meaning and use[M].New York:Marcel Dekker Inc,1999.435-452.
  • 7Tezel C,Ersev AA,Kind H,et al.The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer[J].Thorac Cardiovase Surg,2006 Mar,54(2):124.
  • 8Wulf Siene,IngoMecklenburg,Sebastian Dangu,et al.Detection of MAGE-A Transcripts in BoneMarrow Is an Independent Prognostic Factor in Operable Non-Small-Cell Lung Cancer[J].Clin Cancer Res,2007,13(13):3840-3847.
  • 9Kularatne BY,Lorigan P,Browne S,et al.Monitoring tumour cels in the peripheral blood of small cell lung cancer patients[J].Cytometry,2002,50:160-167.
  • 10Peter J,Sunanda C,Darcas D,et al.Limitations of specific reverse transcrip tase polymerase chain reaction markers in the detection of metases in the lymph nodes and blood of breast cancer patients[J].J Clin Oncol,1998,16(18):2632-2640.

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部