IgA肾病发病机制研究进展

Study Progress about the Pathogenesis of IgA Nephropathy

IgA肾病(IgAN)是最常见的原发性肾小球肾炎,是引起终末期肾衰竭的重要原因之一。IgAN的发病机制很复杂,人们针对其做了很多研究,但结果尚不十分明了。本文主要从IgA结构异常与清除异常、IgAN与循环免疫复合物沉积、IgAN与病原体、IgAN与局部肾素-血管紧张素系统、IgAN与基因以及IgAN与遗传因素及肾移植等方面介绍IgAN发病机制的最新进展。

IgA nephropathy （IgAN）, which can develop into end-stage renal failure, is the most common primary glomerulonephritis worldwide. The pathogenesis of IgAN is very complex. Although a member of researches have been taken,the etiopathogenisis of IgAN is not yet clear. In this paper,the latest progress of IgAN pathogenesis will be introduced in terms of the structural abnormalities of IgA, abnormal IgA clearance, the deposition of circulating immune complex, the pathogens, the local rennin-angiotensin system, the gene, the genetic factors, and the kidney transplantation.