农村居民幽门螺杆菌感染状况及相关因素调查

The studies on the status of helicobacter pylori infection analysis and the factors ralative to infection in rural residents

目的了解农村居民中幽门螺杆菌感染(helicobacter pylori,H pylori)情况,探讨与H pylori感染有关的相关因素。方法采用整群抽样调查方法,抽取河北遵化市下属两农村,以家庭为单位入户进行问卷调查,并采集静脉血检测H pylori-IgG抗体确定H pylori感染情况。结果735例被调查者中H pylori总的感染率为67.35%,但性别间差异无统计学意义(χ2=0.3065,P>0.05)。不同年龄组H pylori感染情况不同(χ2=24.7789,P=0.0004),经趋势χ2检验(χ2=4.5950,P=0.0321),有随年龄增长而上升的趋势。经单因素分析发现,年龄、家庭进餐方式、饮食习惯(如进食水果、辛辣)等与H pylori感染有关。多因素logistic回归分析控制混杂因素后显示,核心家庭实行分餐以及经常摄入水果,会降低感染幽门螺杆菌的风险。结论该地区农村居民的H pylori感染率为67.35%,而且有随着年龄的增长H pylori感染率随之上升的趋势,男女性别间H pylori感染差异无统计学意义。家庭进餐形式、经常吃水果与否与H pylori感染有关联。

[Objective] To explore the helicobacter pylori infection status in rural residents and its correlative factors. [Methods] A questionnaire survey was carried out among rural residents selected by cluster sampling from two villages in Zunhua. Blood sampling was collected to detect helicobacter pylori IgG antibody so as to evaluate the helicobacter pylori infection prevalence. [Results ] The overall prevalence of anti-H pyloriU antibodies in 735 subjects was 67.35%, it was not different between men and women. The infection rate was different in different age groups （XZ=24.7789,P =0.0004）. The prevalence of helicobacter pylori infection increased with age. The difference had statistical significance by test for liner trend （X2=4.5950,P =0.0321）. In the investigation of factors related to helieobacter pylori infection, it was found that in those areas the risk factors of infection were age, several generations eating together, more peppery food and less fruit intake. But according to unconditional logistic regression analysis, only the forms of eating dinners in the families, that was several generations eating together, fruit intake left to influence infection with helicobacter pylori. [ Conclusion ] Helicobacter pylori crude infection rate of this area is higher than the average level in our country. It was increasing with age. We can conclude that dietary habit, several gener- ations eating together might play a important role in helicobacter pylori infection.