吗啡预处理对实验性急性心肌梗塞范围的影响

The effect of morphine pretreatment on acute myocardial infarction

目的为探讨吗啡对心脏的直接作用,在离体全心缺血再灌注模型上观察吗啡预处理对心肌梗塞范围的影响.方法:采用Langendoff离体心脏灌注方法,进行恒压灌注,免心随机分为对照组和吗啡组,均给予30分钟旷置及60分钟再灌注以制备急性心肌梗塞模型.吗啡组给予含0.3um吗啡的灌流液灌注15分钟预处理.心脏行TTC染色,心梗范围用梗死心肌占全心重量的百分比表示.结果:吗啡组心梗范围较对照组明显减少(P<0.05),分别为17.41±5.54%和33.95±12.07%.结论:吗啡预处理可显著地缩小心梗范围,提示吗啡除有镇痛作用外,可能还有限制心梗范围的心肌保护作用.

Objective To investigate the effect of morphine preteatment on acute myocardial infarction. Methods In the Lan-gendoff rabbit heart model, all hearts were subjected to 30 minutes ischemia and 60 minutes reperfusion.In morphine group.0.3μM morphine were perfused for 15 minutes before ischemia.Infarct size was determined by triphenyltetrazolium (TTC) staining, and expressed as a percentage of the whole heart weight.Results The infarct size was 33.95 ± 12.09% in control hearts Morphine could reduce infarct size to 17.41 ±5.54% (P< 0.05)Conclusion Morphine pretreatment can limit infarct size.