情感性精神障碍遗传学家系调查

A genetic epidemiological study of affective disorders

目的评价情感性精神障碍的遗传效应。方法对符合国际疾病分类第１０版和中国精神疾病分类方案与诊断标准第２版修订本中情感性精神障碍诊断的１０２个先证者家系登门调查。结果共调查先证者一、二级亲属４８９８人。１０２个先证者家系精神障碍的阳性率为５８．８％，其中情感性精神障碍同病率为８５．０％，遗传率加权平均值为１０６．３％±２．４％，高发家系为１５０．７％±１４．８％。结论遗传因素在情感性精神障碍病因中具有十分重要地位。

Objective The study was to investigate the mode of transmission of affective disorder. Methods One hundred and two patients,who were firstly admitted to our hospital 30 years ago,were re diagnosed according to the 10th edition of International Classification of Diseases and Chinese Classification and Diagnostic Criteria for Mental Disorders, the Second Revised Edition criteria for affective disorders.All their family members were investigated and analyzed.Results The family prevalence of mental disorders was 58.8%; the concordance rate for affective disorders was 85.0%.The weighted mean of genetic rate was 106.3%±2.4%,and 150.7%± 14.8% in high risk families. Conclusion The genetic factor plays an important role in affective disorders.The heredity model may be a polygenic inheritance with a prominent phenotype.