1Semenza G L,Wang G L. A Nuclear Factor Induced by Hypoxia Via Denovo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation[J]. Mol Cell Biol, 1992,12 (12) :5447-5454.
2Bracken C P, Whitelaw M L, Peet D J. The Hypoxia-inducible Factors : Key Transcriptional Regulators of Hypoxic Responses [J]. Cell Mol Life Sci, 2003,60 : 1376-1393.
3Semenza G L. Regulation of Mammalian O2 Homeostasis by Hypoxia-induced Faetor[J]. Annu Rev Cell Dev Biol, 1999,15:551-578.
4Fedele A O, Whitelaw M L, Peet D J. Regulation of Gene Expression by the Hypoxia Inducible Factors [J]. Mol Interv, 2002,2:229-243.
5Semenza G L, Expression of Hypoxia-inducible Factorl : Mecha nisms and Consequences[J]. Biochem Pharmaeol, 2000,59 : 47- 53.
6Semenza G L. Singnal Trsduction to Hypoxia-inducible Factor 1[J]. Biochem Pharmacot, 2002,64 (5/6) : 993-998.
7Lukiw W J, Ottlecz A, et al. Coordinate Activation of HIF 1 and NF-B DNA Binding and COX 2 and VEGF Expression in Retinal Cells by Hypoxia [J]. Invest Ophthalmol Vis Sci, 2003,44 : 4163-4170.
8Kaur C, Sivakumar V, Foulds W S, et al. Early Response of Neurons and Glial Cells to Hypoxia in the Retina[J]. Invest Ophthalmot Vis Sci,2006,47(3):1126 -1141.
10Ozaki H, Yu A Y, Della N, et al. Hypoxia Inducible Factorlalpha Is Increased in Isehemic Retina: Temporal and Spatial Correlation with VEGF Expression[J]. Invest Ophthalmol Vis Sci, 1999,40 : 182-189.
4Wenger RH,Stiehl DP,Camenisch G.Integration of oxygen signaling at the consensus HRE[J].Sci STKE,2005,306:12
5Lefer DJ.Induction of HIF-1alpha and iNOS with siRNA:a novel mechanism for myocardial protection[J].Circ Res,2006,98 (1):10-11
6Nagle DG,Zhou YD.Natural product-based inhibitors of hypoxiainducible factor-1 (HIF-1)[J].Curr Drug Targets,2006,7 (3):355 -369
7Jiang BH,Semenza GL,Bauer C,et al.Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension[J].Am J Physiol,1996,271:C1172-1180
8Kallio PJ,Pongratz I,Gradin K,et al.Activation of hypoxia-inducible factor 1 α:posttranscriptional regulation and conformational change by recruitment of the are not transcription factor[J].Proc Natl Acad Sci USA,1997,94 (11):5667-5672
9FeiC,VinceC,XiangLS,et al.New insight into the role ofnuclear factor-κB,an ubiquous transcription factor in the initiationof diseases[].Clinical Chemistry.1999
10YoshidaA,YoshidoS,IshibashiT,et al.Suppression of retinalneovascularization by theNF-κB inhibitor pyrrolidinedithiocarbamate in mice[].InvestOphthalmolVisSci.1999
