产ESBLs大肠埃希菌和肺炎克雷伯菌检测及耐药性分析

ESBLs producing escherichia coli and klebsiella pneumoniae detection and analysis of drug resistance

目的研究产ESBLs大肠埃希菌和肺炎克雷伯菌检测及耐药性,指导临床合理应用抗菌药物。方法采用初筛试验和确证试验对临床分离的大肠埃希菌、肺炎克雷伯菌进行检测,以确定产ESBLs菌株,并进行抗生素耐药性分析。结果产ESBLs菌在大肠埃希菌和肺炎克雷伯菌中的检出率分别为44.8%和23.6%,对亚胺培南最为敏感,对头孢唑啉和氨苄西林耐药。结论临床对产ESBLs细菌治疗以碳青霉烯类药物为首选,含酶抑制剂复合药物部分有效。

Objective To study the ESBLs producing Escherichia coli and Klebsiella pneumoniae detection and drug resistance to guide clinical rational use of antimierobial agents. Methods The screening test and confirmatory test against clinical isolates of Escherichia coli , Klebsiella pneumoniae testing to determine the strains producing ESBLs and conduct analysis of antibiotic resistance. Results The bacteria producing ESBLs in E. coli and Klebsiella pneumoniae in the detection rates were 44.8 % and 23.6%, the most sensitive to imipenem, for cefazolin and ampicillin resistance. Conclusion ESBLs producing bacteria on the therapy to carbapenem drugs of choice and compound drugs containing β- lactamases inhibitors partially effective.