组织蛋白酶D在ⅡB型骨肉瘤中的表达及其临床意义

CLINICAL SIGNIFICANCE OF CATHEPSIN D EXPRESSION IN STAGE ⅡB OSTEOSARCOMA

目的探讨组织蛋白酶Ｄ（ＣＤ）与骨肉瘤患者预后的关系。方法应用免疫组化技术检测３４例骨肉瘤组织标本中的ＣＤ表达水平，并结合患者临床病案记录和随访资料进行分析。结果ＣＤ高表达与低表达之间的肿瘤转移人数和２年生存人数差异显著，且ＣＤ低表达患者的平均生存时间较高表达者为长。经Ｋａｐｌａｎ┐Ｍｅｉｅｒ分析，两组间生存率有显著差异。结论ＣＤ高表达的骨肉瘤易发生转移，预后不良，应加强治疗。

Objective:To investigate the prognostic value of cathepsin D (CD) expression in osteosarcoma.Methods:Histological sections of 34 patients with osteosarcoma were detected by immunohistochemistry and analyzed with patients follow up data.Results:The level of CD expression significantly correlated with tumor metastasis and 2 year survival,and the mean period of survival in patients with low level CD expression was significantly longer than that in patients with high level CD expression. Kaplan Meier life table survival of the patients with high level CD expression was significantly worse than that of the patients with low level CD expression.Conclusion:Osteosarcoma with high level CD expression was correlated with metastasis and poor prognosis.