液体复苏加山莨菪碱对烧伤兔心肌功能的影响

Myocardial function after fluid resuscitation with addition of anisodamine in severely burned rabbits

目的探讨山莨菪碱对烧伤兔心肌功能的影响。方法采用新西兰兔25％Ⅲ度烫伤模型,分别于伤前,伤后即刻,1,3,5,7小时测定左心室内压峰值、左心室内压最大变化速率,并观察严重烧伤休克期液体复苏加山莨菪碱对上述指标的影响。结果严重烧伤后早期即发生心肌的收缩功能和舒张功能障碍,并呈进行性减退。单纯给予山莨菪碱或单纯输液治疗对兔严重烧伤后的心功能在短期内有支持作用,但治疗效果欠佳,且单纯山莨菪碱治疗组心功能下降早于单纯补液组。而在给予山莨菪碱同时进行液体复苏。可使心肌收缩性和舒张性在伤后7小时维持在同时相点的假烫组同一水平。结论提示在液体复苏的同时应用山茛菪碱可改善心肌功能,并有利于休克的恢复。

Objective To evaluate the effect of fluid resuscitation with addition of anisodamine (Ani) on myocardial function in severely burned rabbits. Method Ⅲ degree burn injury covering 25% total body surface area (TBSA) was produced on rabbits. LVSP,LV±dp/dt_(max) were measured with fluid resuscitation alone, administration of Ani alone, and fluid resuscitation plus Ani before burn, immediately after burn and 1,3,5,7h after burn. Results It was showed that myocardial contractility and relaxation were depressed 1h after burn. Fluid resuscitation alone and administration of Ani alone could significant- ly improve myocardial contractility and relaxation only within 3h postburn. With fluid resuscitation plus Ani (Stag·kg^(-1)),myocardial contractility and relaxation were improved statistically significantly as compared with control group without treatment (P<0. 01),with the values approaching the normal lev- el. Conclusion Our data demonstrate that the administration of Ani (Stag · kg^(-1)) in addition to fluid resuscitation is beneficial to burn injury, especially to myocardial function, and it provides a promising approach for the future treatment of burns.