摘要
目的探讨下丘脑和垂体γ－氨基丁酸（ＧＡＢＡ）含量变化与机体老化的关系。方法采用放射受体法测定了老年（２４～３６月龄）、中年（１２～１４月龄）、青年（３～５月龄）及２０日龄雌性Ｗｉｓｔａｒ大鼠下丘脑、垂体中ＧＡＢＡ的含量。结果雌性大鼠下丘脑ＧＡＢＡ含量随增龄而增加，老年组明显高于中年、青年和２０日龄组（Ｐ＜０．０５，Ｐ＜０．００１），中年和青年组明显高于２０日龄组（Ｐ＜０．００１），中年与青年组间无明显差异；垂体中ＧＡＢＡ含量随增龄而降低，４组间均有显著性差异（Ｐ＜０．００１）。结论大鼠随月龄增加，下丘脑抑制性ＧＡＢＡ系统功能逐渐增强，垂体ＧＡＢＡ系统功能则逐渐减弱，这种趋势将导致下丘脑调节的神经内分泌功能衰退。
The levels of GABA in hypothalamus and hypophysis were measured in the old(24～26 months), middle(12～14 months),young(3～5 months, and 20 days female Wistar rats. The results showed that the level of GABA in hypothalamus was remarkably increased, in the aging group, The GABA in hypothalamus was remarkably increased than that of middle, young and 20 days group(P<0 05,P<0 01),The levels of GABA in the middle and young groups were remarkably increased than that 20 days groups(P<0 01), but the level of GABA in hypophysis was decreased with aging.The results indicated that the function of GABA inhibition system of hypothalamus progressively enhances, function of GABA system of hypophysis progressively declines with aging. The changes will lead to decline of hypothalamus function that regulates nervous endocrine system. It may be associated with aging of generation endocrine system.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1998年第5期289-290,共2页
Chinese Journal of Gerontology
基金
国家自然科学基金
