针刺治疗血管性痴呆的临床疗效及对超氧化物歧化酶、脂质过氧化物及一氧化氮的影响

Observation of Clinical Effect of Acupuncture on Vascular Dementia and Its Influence on Superoxide Dismutase, Lipid Peroxide and Nitric Oxide

目的 :观察电针、针刺治疗血管性痴呆 (VaD)的疗效及其对超氧化物歧化酶(SOD)、脂质过氧化物 (LPO)、一氧化氮 (NO)的影响。方法 :将 46例血管性痴呆患者按痴呆程度随机分为电针组和针刺组 ,治疗前后分别进行张氏痴呆修改量表 (HDS)、社会活动功能调查表 (FAQ)、神经功能缺损评分对比分析 ,并检测了SOD、LPO、NO的含量。结果 :治疗后电针组HDS增高、FAQ减低 ,SOD上升 ,LPO和NO下降 ,与治疗前比较 ,均有显著性差异 (P <0 0 1 ,P <0 0 0 1 ) ,针刺组上述各项指标治疗前后比较无显著性差异 (P >0 0 5 )。两组临床症状有所改善 ,但神经功能缺损评分减少不明显。电针组总有效率高于针刺组。结论 :电针治疗VaD的近期疗效优于针刺治疗 ,提示电针刺激较单纯针刺更能促进VaD患者智能的康复。

Objective: To observe the clinical effect of electroacupuncture and acupuncture on vascular dementia (VaD) and the influence on superoxide dismutase (SOD), lipid peroxide (LPO) and nitric oxide (NO) levels. Methods: Forty six cases of VaD were randomly divided into two groups, the electroacupuncture group (EA group) and the acupuncture group (AP group). Assessment of Hasgawa's dementia scale (HDS), functional activities questionnaire (FAQ) and neurologic deficit scoring were done before and after treatment, and the changes on SOD, LPO and NO levels were observed. Results: After treatment, in the EA group, the HDS elevated, the FAQ lowered, SOD increased and LPO and NO decreased significantly, as compared with before treatment, P<0 01. But these parameters were not changed significantly in the AP group after treatment. The clinical symptoms were improved in both groups, but the reduction on neurologic deficit score was not significant. The total effective rate of the EA group was higher than that of the AP group. Conclusion: The immediate effect of electroacupuncture was superior to that of acupuncture, suggesting that the electroacupuncture was more effective in promoting the intelligence recovery than acupuncture.