中医肝不同证候血浆去甲肾上腺素和肾上腺素含量及植物神经功能的研究

Studies on Plasma Norepinephrine and Epinephrine Contents and Vegetative Nervous Function in Liver Syndrome

目的 :探讨中医肝不同证候血浆去甲肾上腺素、肾上腺素含量变化规律和植物神经功能失调特征。方法 :证病结合选择研究对象 ;用高效液相色谱 -电化学方法检测血浆去甲肾上腺素、肾上腺素含量 ;植物神经功能检测采用交感、副交感亢进症状 ,生理指标 ,物理负荷试验综合评定。结果 :各实证组血浆去甲肾上腺素、肾上腺素含量增高 ,植物神经功能失调以交感偏亢为主 ;各虚证组血浆去甲肾上腺素、肾上腺素含量降低 ,植物神经功能失调以副交感偏亢为主。结论 :血浆去甲肾上腺素、肾上腺素含量和植物神经功能失调可作为中医肝虚实证候辨证辅助实验诊断指标。

Objective: To study the characteristics of plasma norepinephrine (NE) and epinephrine (E) contents alteration and vegetative nervous function disturbances in patients with Liver Syndrome of TCM. Methods: Subjects were selected by combination of disease diagnosis and Syndrome Differentiation. Plasma NE and E contents were determined by high performance liquid chromatography (HPLC) and electrochemical detector. The vegetative nervous function were assessed by comprehensive analysis of sympathetic and parasympathetic hyperfunction symptoms, physiologic indexes and physical loading tests. Results: Patients of Liver Excess Syndrome had an elevated plasma NE and E contents and with the vegetative nervous system disturbance mainly hypersympathetic. On the contrary, patients of Liver Deficiency Syndrome had an lowered plasma NE and E contents and with the vegetative nervous system disturbance mainly hyperparasympathetic. Conclusion: Plasma NE and E contents and vegetative nervous function disturbance can be taken as the auxiliary laboratory diagnostic indexes for Syndrome Differentiation of Liver Excess and Liver Deficiency.