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乌司他丁对急性重症胰腺炎患者血清IL-6、TNF-α水平及肝肾功能的影响 被引量:23

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摘要 目的探讨乌司他丁治疗急性重症胰腺炎(SAP)的临床效果及可能机制。方法将同期收治的78例SAP患者随机分为观察组38例和对照组40例,两组均予SAP常规治疗,观察组在此基础上予乌司他丁静滴7 d。治疗前后分别检测两组血清IL-6、TNF-α、肝肾功能,观察症状、体征及实验室指标变化并评价其临床疗效。结果治疗7 d后观察组血清IL-6、TNF-α水平及肝肾功能指标均显著低于对照组,总有效率显著高于对照组(P均<0.05)。结论乌司他丁治疗SAP疗效确切,可能机制为改善全身炎症反应及保护肝肾功能。
作者 黄福利
机构地区 郓城县人民医院
出处 《山东医药》 CAS 北大核心 2009年第43期84-85,共2页 Shandong Medical Journal
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