摘要
目的:研究麝香保心丸的舒张血管作用及可能的机制。方法:将离体大鼠动脉环随机分成正常组,去内皮组2组(共为6对动脉环,组内比较用自身对照,组间比较用配对对照)。用去甲肾上腺素诱导动脉环收缩后,加入麝香保心丸,记录反应。结果:麝香保心丸对正常组,去内皮组动脉环均有舒张作用(P<0.01),其效应呈剂量依赖;且其对正常组的舒张作用较去内皮组强(P<0.01)。结论:麝香保心丸具有舒张血管的效应,其机制可能有直接及内皮依赖的舒张血管2种作用。
AIM: To investigate if She_xiang Bao_xin Wan has vasodilative effects.METHODS: Isolated rat aortic rings were randomly divided into normal and denuded groups. The responses of the rings to She_xiang Bao_xin Wan were recorded after norepinephrine_induced constriction. RESULTS: She_xiang Bao_xin Wan dilated normal and denuded aortic rings(n=6 pairs, P<0.01 ) ,and the efficacy was dose_dependent.The drug had a weaker effect on the denuded rings than the normal rings (P<0.01). CONCLUSIONS: She_xiang Bao_xin Wan has vasodilative effects through both endothelium and direct action.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1998年第6期339-341,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
麝香保心丸
胸主动脉
血管舒张
中药药理学
She_xiang Bao_xin Wan
thoracic aorta
vasodilation
Chinese herbal drugs
vascular endothelium