单硝酸异山梨酯、卡托普利与呋塞米联合治疗扩张型心肌病心力衰竭

Isosorbide mononitrate, combined captopril and furosemide in treating heart failure caused by dilated cardiomyopathy

目的：观察单硝酸异山梨酯联合卡托普利、呋塞米治疗扩张型心肌病心力衰竭的疗效。方法：扩张型心肌病心力衰竭病人２６例（男性１８例，女性８例；年龄４５ａ±ｓ７ａ）。以单硝酸异山梨酯２０ｍｇ，ｐｏ，ｂｉｄ；卡托普利６．２５～１２．５ｍｇ，ｐｏ，ｂｉｄ～ｔｉｄ；呋塞米２０ｍｇ，ｐｏ，ｑｄ～ｂｉｄ，２ｗｋ为一个疗程。结果：症状和体征好转；用扇形超声心动图测定ＳＶ，ＣＯ，ＥＦ改善。平均动脉压降低均有显著意义（Ｐ＜０．０５）。心功能（ＮＹＨＡ标准）改善。心率变化不大。总有效率为８１％，未发现严重不良反应。

AIM: To study the efficacy of isosorbide mononitrate combined with captopril and furosemide in treatment of congestive heart failure. METHODS: Twenty_six patients (M 18, F 8, age 45 a±s 7 a) received isosorbide mononitrate 20 mg, po, bid, captopril 6.25_12.5 mg, po, bid_tid, and furosemide 20 mg, po, qd_bid, for 2 wk. RESULTS: The clinical symptoms and signs of all patients were improved. Heart functions (SV, CO, EF) improved obviously (P<0.05) by sector echocardiography scanning. Mean artery pressure declined (P<0.05). Heart rates showed little change (P>0.05). The total effective rate was 81%, no serious adverse reactions were found. CONCLUSION: It is effective to treat congestive heart failure by combining the three drugs.