地尔硫对高血压病左室肥大及心功能的疗效优于复方降压片

Diltiazem is better than Fu_fang Jiang_ya Pian in treating left ventricular hypertrophy and heart function of essential hypertension

目的：比较地尔硫与复方降压片对高血压病左室肥大（ＬＶＨ）及心功能的影响。方法：高血压病伴ＬＶＨ７１例，随机单盲法分为２组。地尔硫组３６例，给地尔硫片６０ｍｇ，ｐｏ，ｔｉｄ×４８ｗｋ；对照组用复方降压片２片，ｐｏ，ｔｉｄ×４８ｗｋ。以多普勒超声心动图评定ＬＶＨ与心功能的变化。结果：２组血压均显著下降（Ｐ＜０．０１），组间比较，Ｐ＞０．０５；地尔硫组ＬＶＨ、左室舒张功能及血液流变学各指标均有显著改善（Ｐ＜０．０１），对照组无上述效应，组间比较，Ｐ＜０．０１。结论：地尔硫对高血压病左室肥厚及心功能的疗效优于复方降压片。

AIM: To compare the effects of diltiazem (Dil) and Fu_fang Jiang_ya Pian on left ventricular hypertrophy (LVH) and heart function of essential hypertension. METHODS: Seventy_one patients with LVH of essential hypertension were randomly divided into two groups: one group (36 patients) was treated with Dil tablet 60 mg, po, tid for 48 wk; the other group (35 patients) was given Fu_fang Jiang_ya Pian 2 tablets, po, tid for 48 wk. The changes of LVH and heart function were determined by Doppler echocardiography. RESULTS: The blood pressure of the two groups decreased (P<0.01). The LVH, left ventricular diastolic function, and hemorheology in Dil group were significantly improved, but in Fu_fang Jiang_ya Pian group there was no effect ( P < 0.01). CONCLUSION: Dil is better than Fu_fang Jiang_ya Pian.