自旋标记的鬼臼葡萄糖苷衍生物的合成

SYNTHESIS OF SPIN LABELED ANALOGUE OF PODOPHYLLOTOXIN GLYCOSIDE

ＶＰ１６２１３（１）和ＶＭ２６（２）的临床有效性及其独特的作用机制一直激励人们去合成抗肿瘤活性更好，毒副作用更低的鬼臼衍生物［１］，ＨｉｔｏｓｈｉＳａｉｔｏ［２～４］等人合成了氨基葡萄糖苷的鬼臼衍生物（３～６）及其异构体，药理实验结果表明，３，...

A novel spin labeled analogue of podophyllotoxin glycoside 9 was synthesized by condensing 4′ demthyl epipodophyllotoxin β D glucopyranose and 4 formyl 2,2,6,6 tetrahydropuridine in presence of p TsOH and triethyl orthoformate. It was shown to exhibit activity compatable to VP 16 213 in inhibiting L 1210 cells.