1690例标本中486株假丝酵母菌的分布及药敏分析

Clinical Distribution and Drug Sensitivity of 486 Strains of Candida in 1,690 Specimens

目的了解假丝酵母菌的临床分布,以及对常用抗真菌药物的耐药性。方法采用回顾性资料分析2008年1月-2009年4月间,临床各种送检标本中假丝酵母菌的分离及耐药性情况。结果从临床送检的痰、尿、分泌物等1 690例标本中检出5种假丝酵母菌共486株,检出率为28.61%,其中白色假丝酵母菌检出325株占66.87%;在各年龄段念珠菌的分布中,60岁以上患者所占比例最大为69.96%;体外药敏试验显示5种假丝酵母菌对两性霉素B、伊曲康唑、制霉菌素的敏感率均在93%以上,对氟康唑的耐药率达到11.5%。结论白色假丝酵母菌仍是第一位的致病性真菌,并且以呼吸道假丝酵母菌感染最常见。5种假丝酵母菌对氟康唑的耐药率最高。

Objective To find out the clinical distribution of Candida and its sensitivity to anti - fungal drugs. Method The candida strains and their drug resistance from clinical specimens from January, 2008 to April, 2009 were analyzed retrospectively. Results Totally 486 strains of Candida spp were detected from the 1,690 clinical submitted specimens of sputum, urine, and secreta, with the detection rate of 28.6196. The candida albicans in 325 sputum specimens was 66.87 %. In the age distribution of the patients with candida infection, the patients aged over 60 years had the largest share, accounted for 66.96 %. In vitro drug sensitivity test showed that their sensitivity rates were over 93 % to amphotericin B, itraconazole, and nystatin, and their drug resistance to fluconazole was 11.5 %. Conclusions Candida albicans is the predominant pathogenic Candida and the respiratory infection is the most common candidiasis. 5 kinds of Candida have the highest resistance rate to fluconazole.