鲍曼不动杆菌临床感染分布和耐药性分析

Analysis on Distribution and Resistance Profile of Infections of Acinetobacter baumannii

目的了解鲍曼不动杆菌临床感染分布和耐药状况。方法应用法国梅里埃VITEK 2微生物鉴定和药敏系统对收集自湖北省荆州市中心医院2008年1月-2009年1月的临床标本进行细菌培养鉴定及药敏分析,用WHONET 5分析试验结果。结果一年间共分离鲍曼不动杆菌104株,痰标本分离率最高达97.12%,主要引起重症监护病房(ICU)患者的下呼吸道感染。该菌耐药性极其严重,对16种常用抗菌药物的耐药率除头孢他啶外,均大于60%。其中25株对16种抗菌药物全部耐药,为泛耐药菌株。结论鲍曼不动杆菌感染以重症监护病房最常见,且多重耐药明显。临床应加强检测,合理使用抗生素,以提高疗效和减缓耐药株的产生。

Objective To determine the distribution and resistance of clinical isolates of Acinetobacter baumannii（Ab）. Methods The bacterial susceptibilities to 16 kinds of antimicrobial agents were determined by automatic microorganism analytical system method using biosMerieumx VITEK 2. The results were analyzed with WHONET 5 software. Results A total of 104 strains were isolated during the period of 2008. The isolation rate of Ab was 97.12 96 in sputum specimens, and majority of the isolates caused lower respiratory tract infection of inpatients in the intensive care unit （ICU）. The resistance of Ab was very serious. Except ceftazi- Dime, those to the other 15 antibiotics resistance were all over 60 %. There were 2.5 pandrug- resistant strains, which were resistant to 16 kinds of antimicrobial agents. Conclusions Acinetobacter baumannii strains were mainly distributed in the ICUs, and moreover, Ab strains show multi - drug resistance. For improving the curative effect and delaying the occurrence of bacteria resistance, it is important to strengthen the clinical monitoring and use antibiotics rationally.