面神经损伤后面神经内压的变化

Changes in endoneurial fluid pressure in the crushed facial nerve

目的研究面神经损伤后神经内压和神经直径的变化，以探讨面神经减压术的必要性以及减压时机的选择。方法采用伺服微变量系统和测微尺对面神经挤压伤后不同时期的豚鼠分别进行神经内压及神经直径的测量。结果面神经高位挤压伤后，神经内压明显改变，压力高峰期在损伤后１周末，平均可达（１２．９４±１．６９）ｍｍＨｇ，为正常值的４～５倍，神经内压的升高持续２周，至第３和第４周恢复正常。面神经直径在伤后１周末最大，平均可达（１．０１±０．０８）ｍｍ。结论伺服测压系统测量实验动物的面神经内压将有助于面瘫病理生理的研究，为临床实施面神经减压术的时机选择提供实验参考。

Objective To investigate the changes in endoneurial fluid pressure (EFP) and diameter of the crushed facial nerves in guinea pigs in order to determine whether there is necessity and the opportunity of the facial nerves decompression in different stage after injury. Methods EFP were measured using a servo nulling micropipette system in the normal and crushed facial nerves. Results The results showed that the EFP in the facial nerve increased significantly after compression. The highest pressure of EFP 12. 94±1.69 mmHg occurred at the end of the first week after injury, which was 4 to 5 times as great as that of normal ones. This change lasted about two weeks,then it returned to normal at the third or the fourth week. The largest diameter of the facial nerve 1.01±0.08 mm was seen at the end of the first week after crush injury. Conclusion It suggested that the servo nulling micropiette system was useful in evaluating the pathogenesis of facial palsy. It could provide the laboratory basis for facial nerve decompression.