细胞间粘附分子在鼻息肉组织中的表达及意义

Expression of intercellular adhesion molecules in nasal polyps tissue and its significance

目的探讨以嗜酸粒细胞浸润为病理特征的鼻息肉组织中局部细胞间粘附分子的表达及其意义。方法对９例正常鼻粘膜和１９例鼻息肉组织冰冻切片，用细胞间粘附分子１（ｉｎｔｅｒｃｅｌｕｌａｒａｄｈｅｓｉｏｎｍｏｌｅｃｕｌｅ１，ＩＣＡＭ１）和淋巴细胞功能相关抗原１（ｌｙｍｐｈｏｃｙｔｅｆｕｎｃｔｉｏｎａｓｏｃｉａｔｅｄａｎｔｉｇｅｎ１，ＬＦＡ１）单抗进行免疫组织化学及其与ＭＧＧ（ＭａｙＧｒüｗａｌｄＧｉｅｍｓａ）双染，光镜观察。结果与对照组相比，鼻息肉组织ＩＣＡＭ１和ＬＦＡ１的表达均显著增加，组织局部ＩＣＡＭ１的表达与大量ＬＦＡ１阳性的嗜酸粒细胞浸润密切相关。结论鼻息肉组织ＩＣＡＭ１和ＬＦＡ１的高表达，ＩＣＡＭ１／ＬＦＡ１相互作用促进了嗜酸粒细胞浸润，参与了局部的炎症过程，细胞间粘附分子（ＩＣＡＭ１／ＬＦＡ１）的高表达是鼻息肉发生、发展诸多因素中的重要因素之一。

Objective To study the expression of intercellular adhesion molecule 1/lymphocyte function associated antigen 1 in nasal polyps tissue and its significance. Methods Frozen sections of 9 normal nasal mucosa and 19 nasal polyp samples were studied with immunohistochemical technique and immunohistochemical and MGG dual staining method with ICAM 1 and LFA 1 monoclone antibodies. Results Expression of ICAM 1 and LFA 1 were stronger in nasal polyps tissue than in the normal nasal mucosa, and there is positive relationship between the expression of ICAM 1 and the expression of LFA 1 on eosinophils. Conclusion High expression of ICAM 1 and LFA 1 in nasal polyps tissue showed that interaction of ICAM 1/LFA 1 may participate in the inflammatory reaction and prompt adhesion and migration of eosinophils. High expression of LFA 1 + on eosinophils may play an important role in the pathogenes of nasal polyps.